1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 3-iodo-
4-Amino-3-Iodo-1H-Pyrazolo[3,4-D]Pyrimidine
CAS: 151266-23-8
Molecular Formula: C5H4IN5
1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 3-iodo- - Names and Identifiers
1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 3-iodo- - Physico-chemical Properties
| Molecular Formula | C5H4IN5 |
| Molar Mass | 261.02 |
| Density | 2.92±0.1 g/cm3(Predicted) |
| Boling Point | 312.3±52.0 °C(Predicted) |
| Appearance | powder to crystal |
| Color | White to Light yellow to Light orange |
| Maximum wavelength(λmax) | ['282nm(lit.)'] |
| pKa | 10.50±0.20(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
| Sensitive | Light Sensitive |
| MDL | MFCD03787931 |
1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 3-iodo- - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R22 - Harmful if swallowed |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S37 - Wear suitable gloves. |
| TSCA | N |
| HS Code | 29335990 |
1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 3-iodo- - Reference Information
| Application | 4-amino-3-iodo-1H-zolololo [3,4-D] pyrimidine can be used as a reagent for the discovery and preparation of CHMFL-FLT3-122, and can be used as an oral and effective FLT3-ITD-positive acute myeloid leukemia inhibitor. Develop and prepare effective and selective Plasmodium falciparum calcium-dependent protein kinase 4(PfCDPK4) inhibitors, which can prevent the transmission of malaria to mosquitoes. |
| Use | 4-amino -3-iodo-1H-zololo [3,4-D] pyrimidine is a reagent used to detect and synthesize CHMFL-FLT3-122, CHMFL-FLT3-122 is an effective oral FLT3 kinase inhibitor for the treatment of FLT3-itd-positive acute myeloid leukemia. It is used to develop and prepare powerful and selective inhibitors of calcium-dependent protein kinase 4(PfCDPK4) of Plasmodium falciparum to prevent the transmission of malaria to mosquitoes. |
Last Update：2024-04-09 21:54:55
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